In an interview with Figure Four Daily (via Crunchgear) EA MMA producer Jeff Ecker unequivocally stated there will be an EA Sports MMA 2. While Ecker declared it was not a matter of “if” but “when”, the original plan was to alternate years with the Fight Night franchise. That would put the next EA MMA on schedule to release in 2012.
source: http://www.pastapadre.com/2010/12/01/ea-sports-mma-sequel-confirmed